Gleevec medication for cml and sperm
Will Imatinib Compromise Reproductive Capacity?
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BACKGROUND: Imatinib is a first-line tyrosine kinase inhibitor for treating chronic CML-CP patients treated with imatinib exhibited reduced sperm density.
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Description:However, total number of sperm per ejaculate is another important measure for clinicians to provide advice to patient couples [ 19 - 21 ]. Once a follicle is selected, estradiol is produced, which creates a negative feedback loop on the pituitary and subsequently suppresses FSH such that only a single mature follicle develops. N Engl J Med Defective sperm flagellar motility and hyperactivated motility, production of volume changes that negatively affect motility of the sperm as well as defective capacitation of the sperms have been observed in animal studies [ 24 - 31 ]. We therefore assessed the effect of imatinib on human luteinized mural granulosa cells in primary culture for any global effects on cell growth and survival by measuring cellular protein levels.
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